Cooperative Research and Development Agreement (CRADA) is an agreement between a government agency and a private company or university to work together on research and development.
Designated under the Federal Technology Transfer Act of 1986 (P.L. 99-502) (which amended the Stevenson-Wydler Technology Innovation Act of 1980 (P.L. 96-480) ), a CRADA is intended to speed the commercialization of technology, optimize resources, and protect the private company involved.
A CRADA allows both parties to keep research results confidential for up to five years under the Freedom of Information Act. The Office of Scientific and Technical Information (OSTI) is responsible for preserving the scientific and technical information generated through a CRADA and making this information readily available to the scientific community as well as the public. Private corporations participating in a CRADA are allowed to file for patent, and they retain patent rights on inventions developed by the CRADA. The government gets a license to the patents.

The CRADA is between the Hollings Marine Laboratory, a Unit of the National Oceanic and Atmospheric Administration (National Ocean Service, National Centers Coastal Ocean Science, Center for Human Health Risk, Hollings Marine Laboratory or NOAA), and American Marine University Research Institute, Inc. (AMURI), Collaborator. CRADA Identification Number: TT-000283
Project Title: Development and testing of ozone impregnated nano bubble technology to address national water safety and security issues
Project Duration: 5 years

Preferred Partners
In choosing which public and private entities to establish close working relationships with, AMURI employs the following criteria:
- Rights to the technology
- Business integrity
- Financial strength
- Ability to perform
Technical Statement of Work (SoW)
American Marine University Research Institute, Inc. (AMURI) is a non-profit organization dedicated to providing clean, safe, and usable water globally.
The objectives of this project are to develop for commercial use, ozone (and other gases) impregnated with nano bubble technology (NBOT) to address a number of water safety and security issues including: algae mitigation / remediation; toxin identification / degradation / elimination; elimination of water contaminants, herbicides, pesticides, etc. and overall water sterilization.
As part of this research project, the NOAA/HML PI and the Collaborator scientists and lab technicians will conduct experiments to assess the efficacy of NBOT in both microbial mitigation (sterilization) as well as toxin and other chemical contaminant degradation. The research will require the identification of unknown bioactive compounds (natural products chemistry) for assessment, analysis and testing of the NBOT algae and toxin mitigation technology.